Supplementary Figures 1 - 5 from Multifactorial T-cell Hypofunction That Is Reversible Can Limit the Efficacy of Chimeric Antigen Receptor–Transduced Human T cells in Solid Tumors
Autor: | Steven M. Albelda, E. John Wherry, James L. Riley, Carl H. June, Michael C. Milone, Ellen Puré, John Scholler, Veena Kapoor, Jing Sun, Raghuveer Ranganathan, Caleph B. Wilson, Douglas V. Dolfi, Liang-Chuan Wang, Edmund K. Moon |
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Rok vydání: | 2023 |
DOI: | 10.1158/1078-0432.22447665.v1 |
Popis: | PDF file - 756K, Supplemental Fig 1. EMP and EMMESO mesothelin expression. Supplemental Fig 2. EMMESO flank tumors retain antigen expression in vivo. Supplemental Fig 3. MesoCAR TILs are unable to secrete IL-2 in response to antigen. Supplemental Fig 4. Supplemental IL-2 helps but is not necessary for CAR TIL recovery. Supplemental Fig 5. IFNγ and TNFα secretion by CAR TILs recovers after resting away from tumor. |
Databáze: | OpenAIRE |
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