Prostate cancer and the unfolded protein response
| Autor: | Margrethe Storm, Yke Jildouw Arnoldussen, Xia Sheng, Fahri Saatcioglu |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Male
0301 basic medicine therapeutic targeting Review Calcium in biology 03 medical and health sciences Prostate cancer Organelle medicine Animals Humans business.industry Endoplasmic reticulum Prostatic Neoplasms Cancer prostate cancer medicine.disease Cell biology 030104 developmental biology Oncology Immunology Unfolded Protein Response endoplasmic reticulum stress Unfolded protein response Protein folding Organelle biogenesis business |
| Zdroj: | Oncotarget |
| ISSN: | 1949-2553 |
| Popis: | The endoplasmic reticulum (ER) is an essential organelle that contributes to several key cellular functions, including lipogenesis, gluconeogenesis, calcium storage, and organelle biogenesis. The ER also serves as the major site for protein folding and trafficking, especially in specialized secretory cells. Accumulation of misfolded proteins and failure of ER adaptive capacity activates the unfolded protein response (UPR) which has been implicated in several chronic diseases, including cancer. A number of recent studies have implicated UPR in prostate cancer (PCa) and greatly expanded our understanding of this key stress signaling pathway and its regulation in PCa. Here we summarize these developments and discuss their potential therapeutic implications. |
| Databáze: | OpenAIRE |
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