Seroprevalence and Risk Factors Possibly Associated with Emerging Zoonotic Vaccinia Virus in a Farming Community, Colombia

Autor: Gina Paez Olaya, Claudia Patricia Torres, Alejandra Pinilla Farias, Matthew R. Mauldin, Mary G. Reynolds, Leidy Laura López Sepúlveda, Carlos Elkin Riveros, Martha Gracia-Romero, Brett W. Petersen, Ashley Styczynski, Katherine D Laiton, José A. Usme-Ciro, Leydi Acosta Lopez, Diana Yaneth Cepeda, Juan Martínez-Cerón, Yoshinori Nakazawa, Faiber Antonio Gutierrez Lozada, Daniela Gomez Espinosa, Clint N Morgan, Panayampalli Subbian Satheshkumar, Whitni Davidson, Diana M. Walteros, Yu Li, Christina Chapman, Edilson Patiña, Anyely Eliana Cruz Suarez, Jillybeth Burgado
Rok vydání: 2019
Předmět:
Male
Epidemiology
animal diseases
viruses
lcsh:Medicine
orthopoxvirus
Disease
Communicable Diseases
Emerging
chemistry.chemical_compound
0302 clinical medicine
Risk Factors
Seroepidemiologic Studies
Zoonoses
Vaccinia
orthopox virus
030212 general & internal medicine
Orthopoxvirus
Child
Smallpox vaccine
Aged
80 and over
biology
Zoonosis
food and beverages
virus diseases
Agriculture
Middle Aged
vaccinia virus
Infectious Diseases
Synopsis
Female
Adult
Microbiology (medical)
Adolescent
030231 tropical medicine
Colombia
Virus
lcsh:Infectious and parasitic diseases
Young Adult
03 medical and health sciences
Seroprevalence and Risk Factors Possibly Associated with Emerging Zoonotic Vaccinia Virus in a Farming Community
Colombia
Environmental health
medicine
Animals
Humans
Seroprevalence
lcsh:RC109-216
zoonotic
Aged
business.industry
lcsh:R
dairy farms
Outbreak
medicine.disease
biology.organism_classification
respiratory tract diseases
Immunoglobulin M
chemistry
Immunoglobulin G
business
Zdroj: Emerging Infectious Diseases, Vol 25, Iss 12, Pp 2169-2176 (2019)
Emerging Infectious Diseases
ISSN: 1080-6059
1080-6040
Popis: Dairy farmers had high rates of orthopoxvirus seropositivity and substantial illness associated with vaccinia-like lesions.
In 2014, vaccinia virus (VACV) infections were identified among farmworkers in Caquetá Department, Colombia; additional cases were identified in Cundinamarca Department in 2015. VACV, an orthopoxvirus (OPXV) used in the smallpox vaccine, has caused sporadic bovine and human outbreaks in countries such as Brazil and India. In response to the emergence of this disease in Colombia, we surveyed and collected blood from 134 farmworkers and household members from 56 farms in Cundinamarca Department. We tested serum samples for OPXV antibodies and correlated risk factors with seropositivity by using multivariate analyses. Fifty-two percent of farmworkers had OPXV antibodies; this percentage decreased to 31% when we excluded persons who would have been eligible for smallpox vaccination. The major risk factors for seropositivity were municipality, age, smallpox vaccination scar, duration of time working on a farm, and animals having vaccinia-like lesions. This investigation provides evidence for possible emergence of VACV as a zoonosis in South America.
Databáze: OpenAIRE
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