Repurposing of MitoTam: Novel Anti-Cancer Drug Candidate Exhibits Potent Activity against Major Protozoan and Fungal Pathogens

Autor:	Dominik Arbon, Kateřina Ženíšková, Karolína Šubrtová, Jan Mach, Jan Štursa, Marta Machado, Farnaz Zahedifard, Tereza Leštinová, Carolina Hierro-Yap, Jiri Neuzil, Petr Volf, Markus Ganter, Martin Zoltner, Alena Zíková, Lukáš Werner, Robert Sutak
Rok vydání:	2022
Předmět:	Membrane Potential Mitochondrial Pharmacology Infectious Diseases Plasmodium falciparum Trypanosoma brucei brucei Drug Repositioning Animals Antineoplastic Agents Pharmacology (medical)
Zdroj:	Antimicrobial Agents and Chemotherapy. 66
ISSN:	1098-6596 0066-4804
Popis:	Many of the currently available anti-parasitic and anti-fungal frontline drugs have severe limitations, including adverse side effects, complex administration, and increasing occurrence of resistance. The discovery and development of new therapeutic agents is a costly and lengthy process. Therefore, repurposing drugs with already established clinical application offers an attractive, fast-track approach for novel treatment options. In this study, we show that the anti-cancer drug candidate MitoTam, a mitochondria-targeted analog of tamoxifen, efficiently eliminates a wide range of evolutionarily distinct pathogens
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::141ef95377638cf2f61e9834eb67eeca https://doi.org/10.1128/aac.00727-22 Zobrazit plný text záznamu