Metabolism of fluorine 18 in domestic animals
| Autor: | Ira B. Whitney, C. L. Comar, W. E. Lotz, Robert A. Monroe, Jesse D. Perkinson |
|---|---|
| Rok vydání: | 1955 |
| Předmět: |
Radioisotopes
medicine.medical_specialty Fluorine Radioisotopes chemistry.chemical_element Fluorine Biology Calcium Intestinal absorption Excretion Rumen Fluorides Endocrinology Radioactivity chemistry Blood chemistry Physiology (medical) Internal medicine Animals Domestic Toxicity medicine Ingestion Animals Reticulum |
| Zdroj: | The American journal of physiology. 182(2) |
| ISSN: | 0002-9513 |
| Popis: | Amounts of F/sup 18/ sufficient to permit studies up to 10 hours duration in domestic animals with non-toxic levels of total fluorine have become available from cyclotron production. The initial rate of disappearance of intravenously injected F/sup 18/ from the blood was found to be 41 and 32% of the dose/min. for the lamb and a mature cow, respectively. The over-all disappearance curve was resolved into 4 components, similar to comparable curves reported for calcium 45. Data from both sheep and cow experiments showed that absorption was rapid, probably occurring from the rumen. Generally, about 1% of the ingested dose represented the peak blood value which occurred at about 2 and 5 hours in the sheep and cow, respectively. The selective localization of F/sup 10/ in the skeleton appeared to be similar to that of calcium as judged from bone and mandible autoradiograms. It was shown that some of the ingested F/sup 18/ was deposited in various parts of the hen's egg and in cow's milk. 13 references, 5 figures, 3 tables. |
| Databáze: | OpenAIRE |
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