Scope and Limitations of Solid-Supported Liquid−Liquid Extraction for the High-Throughput Purification of Compound Libraries

Autor:	Kelly J. McClure, J. Guy Breitenbucher, and Kristen L. Arienti
Rok vydání:	2001
Předmět:	chemistry.chemical_classification Solvent Liquid–liquid extraction Chemistry Compatibility (mechanics) General Chemistry Combinatorial chemistry Organic compound
Zdroj:	Journal of Combinatorial Chemistry. 3:528-533
ISSN:	1520-4774 1520-4766
Popis:	This paper reports some of the advantages and limitations of solid-supported liquid-liquid extraction (SLE) for the rapid purification of organic compound libraries. Issues of solvent compatibility, compound compatibility, and technical methods are addressed. In addition the prospective use of calculated log P values is investigated to determine which impurities will be effectively removed by this technique. In addition SLE is shown to be complementary and in some cases superior to solid-phase extraction (SPE) methods for library purification. This is especially true when the desired products have functionality equivalent to that of the impurity to be removed.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::141b5a2d68c2180d4c3c8e98cc0edf8e https://doi.org/10.1021/cc010039f Zobrazit plný text záznamu