Atopic manifestations are more common in patients with Crohn disease than in the general population
| Autor: | Monika Dufmats, O Lannerstad, Pär Myrelid, Rune Sjödahl, C Grännö, Ingela Lilja |
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| Rok vydání: | 2004 |
| Předmět: |
Adult
Hypersensitivity Immediate Male medicine.medical_specialty Allergy Rhinitis Allergic Perennial Adolescent Population Eczema Logistic regression Atopy Crohn Disease Internal medicine Immunopathology Medicine Humans education Asthma education.field_of_study business.industry Gastroenterology Rhinitis Allergic Seasonal Odds ratio Middle Aged medicine.disease Immunology Tumor necrosis factor alpha Female business |
| Zdroj: | Scandinavian journal of gastroenterology. 39(8) |
| ISSN: | 0036-5521 |
| Popis: | Background: The role of TNF-α in Crohn disease is now well established and anti-TNF-α is frequently used as a second- or third-line treatment. Tumor necrosis factor-α (TNF-α) is traditionally associated with macrophages but has recently also been found in mast cells of the ileal wall in patients with Crohn disease. As it is well known that mast cells and TNF-α play important roles in atopic manifestations like asthma, allergic rhinitis, and eczema the aim of this study was to investigate whether these are seen more commonly in Crohn patients than in the general population. Methods: Patients with Crohn disease (n = 308), aged 18-50 years, living in the Linkoping region in southeast Sweden, were asked to answer a questionnaire regarding the presence of any kind of atopic manifestations. The questionnaire was also sent to 930 controls collected from the Southeastern Region Population Registry. The controls were matched according to age, sex, and place of residence. Results: The response rate among the Crohn patients was 91% (280/308) and among controls 84% (779/930). Eczema was a significantly more frequent manifestation, being almost twice as common in Crohn patients (27%) as in the general population (16%). Adjustment by logistic regression for place of residence, gender, age and coexistence of any other atopic manifestation did not change the odds ratios significantly. Conclusion: Atopic manifestations as a group, and eczema as a single manifestation, are significantly more frequent in Crohn patients than in the general population. |
| Databáze: | OpenAIRE |
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