Glatiramer acetate increases T- and B -regulatory cells and decreases granulocyte-macrophage colony-stimulating factor (GM-CSF) in an animal model of multiple sclerosis
| Autor: | Michael Sela, Sandra Leistner-Segal, Ruth Arnon, Dana Hirsch, Rina Aharoni, Lihi Radomir, Tali Feferman, Nofar Schottlender, Raya Eilam |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Multiple Sclerosis Immunology Mice Transgenic T-Lymphocytes Regulatory Mice 03 medical and health sciences 0302 clinical medicine Animal model medicine Animals Immunology and Allergy Glatiramer acetate B-Lymphocytes Regulatory Chemistry Multiple sclerosis Experimental autoimmune encephalomyelitis Therapeutic effect Granulocyte-Macrophage Colony-Stimulating Factor Glatiramer Acetate medicine.disease Mice Inbred C57BL Disease Models Animal 030104 developmental biology Granulocyte macrophage colony-stimulating factor Neurology Mechanism of action Mrna level Female Neurology (clinical) medicine.symptom Immunosuppressive Agents 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Journal of Neuroimmunology. 345:577281 |
| ISSN: | 0165-5728 |
| Popis: | To identify the mechanisms relevant for the therapeutic effect of glatiramer acetate (GA), we studied T- and B- regulatory cells as well as GM-CSF expression in mice recovered from experimental autoimmune encephalomyelitis (EAE). Selective depletion of Tregs reduced but did not eliminate the ability of GA to ameliorate EAE, indicating a role for additional immune-subsets. The prevalence of Bregs in the periphery and the CNS of EAE-mice increased following GA-treatment. Furthermore, GA downregulated the pathological expression of GM-CSF, on both the protein and mRNA levels. These findings corroborate the broad immunomodulatory mechanism of action of GA in EAE/MS. |
| Databáze: | OpenAIRE |
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