Host Protease Activity on Bacterial Pathogens Promotes Complement and Antibiotic-Directed Killing
| Autor: | Alexandria-Jade Roberts, Shaorong Chen, Carolyn L. Cannon, Dongmei Zhang, Qing-Ming Qin, Paul de Figueiredo, Hsueh-Chung Lu |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Microbiology (medical)
medicine.drug_class medicine.medical_treatment Antibiotics medicine.disease_cause antibiotics Microbiology Immune system bacterial pathogens medicine Immunology and Allergy Molecular Biology Protease General Immunology and Microbiology biology multidrug resistant bacteria Pseudomonas aeruginosa Communication biology.organism_classification protease neutrophil elastase Acinetobacter baumannii Complement system Infectious Diseases Neutrophil elastase host complement system biology.protein Medicine host immune system Bacteria |
| Zdroj: | Pathogens, Vol 10, Iss 1506, p 1506 (2021) Pathogens |
| ISSN: | 2076-0817 |
| Popis: | Our understanding of how the host immune system thwarts bacterial evasive mechanisms remains incomplete. Here, we show that host protease neutrophil elastase acts on Acinetobacter baumannii and Pseudomonas aeruginosa to destroy factors that prevent serum-associated, complement-directed killing. The protease activity also enhances bacterial susceptibility to antibiotics in sera. These findings implicate a new paradigm where host protease activity on bacteria acts combinatorially with the host complement system and antibiotics to defeat bacterial pathogens. |
| Databáze: | OpenAIRE |
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