Potential of Bryophyllum pinnatum as a Detrusor Relaxant: An in Vitro Exploratory Study

Autor: Karin Fürer, Ursula von Mandach, Ana Paula Simões-Wüst, Simon Bachmann, Olivier Potterat, Cornelia Betschart, Mónica Mennet, Matthias Hamburger, Julia Gerber
Přispěvatelé: University of Zurich, Simões-Wüst, Ana Paula
Jazyk: angličtina
Rok vydání: 2017
Předmět:
Kalanchoe
Male
Contraction (grammar)
Swine
Muscle Relaxation
Flavonoid
3003 Pharmaceutical Science
Pharmaceutical Science
Pharmacology
01 natural sciences
Analytical Chemistry
0302 clinical medicine
Drug Discovery
chemistry.chemical_classification
1602 Analytical Chemistry
Urinary bladder
biology
3002 Drug Discovery
2707 Complementary and Alternative Medicine
food and beverages
10174 Clinic for Gynecology
Muscle relaxation
medicine.anatomical_structure
3004 Pharmacology
Overactive bladder
030220 oncology & carcinogenesis
Molecular Medicine
Female
610 Medicine & health
In Vitro Techniques
Contractility
03 medical and health sciences
medicine
Bryophyllum pinnatum
Animals
10026 Clinic for Obstetrics
Flavonoids
Plant Extracts
Urinary Bladder
Overactive
fungi
Organic Chemistry
biology.organism_classification
medicine.disease
In vitro
0104 chemical sciences
Bufanolides
010404 medicinal & biomolecular chemistry
Complementary and alternative medicine
chemistry
1313 Molecular Medicine
1605 Organic Chemistry
Popis: An earlier prospective, randomised, placebo-controlled clinical trial had suggested that Bryophyllum pinnatum might have potential in the treatment of overactive bladder. Here we investigated the effects of B. pinnatum leaf press juice, fractions enriched in flavonoids and bufadienolides, and a flavonoid aglycon mixture and individual aglycons on detrusor contractility as a major target in overactive bladder treatment. The strength of the detrusor contractions was investigated using porcine muscle strips stimulated with KCl. B. pinnatum leaf press juice increased the contraction force of muscle strips. Treatment with the flavonoid-enriched fraction had almost no effect on contractility, while the bufadienolide-enriched fraction and flavonoid aglycons led to a concentration-dependent lowering of the contraction force. The data indicate that several components of B. pinnatum leaf press juice may contribute to the inhibitory effect on detrusor contractility, which in turn provides support to overactive bladder treatment with B. pinnatum.
Databáze: OpenAIRE
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