The metalloproteinase inhibitor GI5402 inhibits endotoxin-induced soluble CD27 and CD16 release in healthy humans

Autor:	Pascale E. P. Dekkers, P. Lumley, H. R. Koene, F. N. Lauw, T. Ten Hove, T. van der Poll, S. J. H. Van Deventer
Přispěvatelé:	Other departments
Jazyk:	angličtina
Rok vydání:	2000
Předmět:	Adult Lipopolysaccharides Male Health Status Immunology Cell chemical and pharmacologic phenomena Matrix Metalloproteinase Inhibitors Biology Matrix metalloproteinase Pharmacology CD16 Microbiology Immune system Oral administration immune system diseases medicine Humans Enzyme Inhibitors Receptor Host Response and Inflammation Receptors IgG virus diseases Biological activity hemic and immune systems Matrix Metalloproteinases Tumor Necrosis Factor Receptor Superfamily Member 7 Infectious Diseases medicine.anatomical_structure Solubility Enzyme inhibitor biology.protein Parasitology
Zdroj:	Infection and immunity, 68(5), 3036-3039. American Society for Microbiology
ISSN:	0019-9567
Popis:	Metalloproteinases have been implicated in the cleavage of a number of cell surface immune receptors. Oral administration of the metalloproteinase inhibitor GI5402 attenuated the release of soluble CD27 and CD16 into the circulation after intravenous endotoxin injection in healthy humans.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1418aad557f5923810792f9e3876d1d6 https://pure.amc.nl/en/publications/the-metalloproteinase-inhibitor-gi5402-inhibits-endotoxininduced-soluble-cd27-and-cd16-release-in-healthy-humans(306ffa2e-5129-468d-a687-2aeba56431c5).html Zobrazit plný text záznamu