Impact of varicocele on biological markers of gonadal function
| Autor: | Maria Raissaki, G. Sakellaris, D. I. Anyfantakis, E. Blevrakis, E. Chatzidarellis, O. Zoras, Charalampos Mamoulakis, Frank Sofras, Emmanuel Chrysos |
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| Rok vydání: | 2015 |
| Předmět: |
Male
medicine.medical_specialty Adolescent Varicocele 030232 urology & nephrology Urology Gonadotropin-Releasing Hormone 03 medical and health sciences 0302 clinical medicine Humans Medicine Inhibins Testosterone Inhibin b 030219 obstetrics & reproductive medicine business.industry Potential effect Luteinizing Hormone medicine.disease Gonadotropins Pituitary Surgery Follicle Stimulating Hormone business Biomarkers Abdominal surgery Hormone |
| Zdroj: | Hernia. 20:435-439 |
| ISSN: | 1248-9204 1265-4906 |
| DOI: | 10.1007/s10029-015-1361-x |
| Popis: | The aim of this study is to evaluate the potential effect of varicocele in the hormonal and clinical profile of adolescents.Twenty adolescents at Tanner stage 4-5 with left varicocele were studied and compared with a control group of 20 healthy adolescents. All patients underwent ultrasonographic testicular volumetry as well as hormonal evaluation of inhibin B, testosterone, baseline and gonadotropin-releasing hormone stimulated, follicle-stimulating hormone as well as luteinizing hormone. Statistical analysis was performed using the student's t test with p value0.05 taken as statistical significant.Patients with varicocele showed reduced levels of inhibin B compared to controls and a significant reduction in the testicular volume on the affected side. The response of luteinizing hormone to gonadotropin-releasing hormone stimulation was significantly higher in the varicocele group compared to the control group. Furthermore a significant inverse relationship of inhibin B compared to follicle-stimulating hormone was noted.Serum inhibin B levels could represent a useful marker of Sertoli cell damage caused by varicocele. |
| Databáze: | OpenAIRE |
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