Can metabolically healthy obesity be explained by diet, genetics, and inflammation?
| Autor: | Estanislau Navarro, Montserrat Fitó, Helmut Schröder, Anna N. Funtikova |
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| Rok vydání: | 2014 |
| Předmět: |
medicine.medical_specialty
Phytochemicals Anti-Inflammatory Agents Adipose tissue Biology Antioxidants Epigenesis Genetic chemistry.chemical_compound Internal medicine Adipocyte Diabetes mellitus Metabolically healthy obesity medicine Genetic predisposition Animals Humans Genetic Predisposition to Disease Obesity Life Style Inflammation Clinical Trials as Topic Genetics of obesity Polyphenols Vitamins medicine.disease Diet Disease Models Animal Endocrinology Phenotype chemistry Adipose Tissue Fatty Acids Unsaturated Dyslipidemia Food Science Biotechnology |
| Zdroj: | Molecular nutritionfood research. 59(1) |
| ISSN: | 1613-4133 |
| Popis: | A substantial proportion of obese individuals do not present cardiometabolic complications such as diabetes, hypertension, or dyslipidemia. Some, but not all, prospective studies observe similar risk of cardiovascular events and all-cause mortality among individuals with this so-called "metabolically healthy obese" (MHO) phenotype, compared to the metabolically healthy normal weight or metabolically healthy non-obese phenotypes. Compared to the metabolically unhealthy obese (MUO) phenotype, MHO is often characterized by a more favorable inflammatory profile, less visceral fat, less infiltration of macrophages into adipose tissue, and smaller adipocyte cell size. Tipping the inflammation balance in adipose tissue might be particularly important for metabolic health in the obese. While the potential role of genetic predisposition or lifestyle factors such as diet in the MHO phenotype is yet to be clarified, it is well known that diet affects inflammation profile and contributes to the functionality of adipose tissue. This review will discuss genetic predisposition and the molecular mechanisms underlying the potential effect of food on the development of the metabolic phenotype characteristic of obesity. |
| Databáze: | OpenAIRE |
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