Association between metabolically healthy central obesity in women and levels of soluble receptor for advanced glycation end products, soluble vascular adhesion protein-1, and activity of semicarbazide-sensitive amine oxidase

Autor: Éva Szökő, Radana Gurecká, Ivana Koborová, Katarína Šebeková, Melinda Csongová, Tamás Tábi, Katarina Volkovova
Rok vydání: 2017
Předmět:
Adult
0301 basic medicine
medicine.medical_specialty
Receptor for Advanced Glycation End Products
Adipokine
030204 cardiovascular system & hematology
03 medical and health sciences
0302 clinical medicine
Insulin resistance
Pregnancy
Risk Factors
Glycation
Internal medicine
medicine
Humans
Inflammation
Metabolic Syndrome
Anthropometry
medicine.diagnostic_test
biology
Adiponectin
business.industry
C-reactive protein
General Medicine
Middle Aged
Clinical Science
medicine.disease
Lipids
Pregnancy Complications
C-Reactive Protein
030104 developmental biology
Endocrinology
Biochemistry
Blood chemistry
Cardiovascular Diseases
Obesity
Abdominal
biology.protein
Female
Amine Oxidase (Copper-Containing)
Inflammation Mediators
Insulin Resistance
Metabolic syndrome
Lipid profile
business
Cell Adhesion Molecules
Biomarkers
Zdroj: Croatian Medical Journal
Volume 58
Issue 2
ISSN: 1332-8166
0353-9504
DOI: 10.3325/cmj.2017.58.106
Popis: Aim To determine the levels of circulating soluble receptor for advanced glycation end products (sRAGE), as a biomarker of risk of metabolic syndrome and cardiovascular disease development in centrally obese (CO) women considered metabolically healthy (COH) in comparison with those metabolically unhealthy (COU). Methods 47 lean healthy, 17 COH (presenting waist-to-height ratio ≥0.5 but not elevated blood pressure, atherogenic lipid profile, and insulin resistance), and 50 COU (CO presenting ≥2 risk factors) women aged 40-45 years were included. Anthropometric characteristics, blood chemistry and hematology data, adipokines, markers of inflammation, sRAGE, soluble vascular adhesion protein-1 (sVAP-1), and the activity of semicarbazide sensitive amine oxidase (SSAO) were determined. Results Central obesity associated with low sRAGE levels (lean healthy: 1503 ± 633 pg/mL; COH: 1103 ± 339 pg/mL, P
Databáze: OpenAIRE
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