Visible‐Light‐Mediated Dearomatisation of Indoles and Pyrroles to Pharmaceuticals and Pesticides
| Autor: | Shoubhik Das, Yu Zhang, Waldemar Schilling, Daniel Riemer |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Indoles
Light heterocycles homogeneous catalysis oxygenation pharmaceuticals photocatalysis Single step Homogeneous catalysis 010402 general chemistry Imides 01 natural sciences Pyrrole derivatives Catalysis chemistry.chemical_compound Pyrroles Pesticides Indole test 010405 organic chemistry Chemistry Isatin Communication Organic Chemistry General Chemistry Pesticide Combinatorial chemistry Communications 0104 chemical sciences Homogeneous Catalysis Pharmaceutical Preparations Photocatalysis Visible spectrum |
| Zdroj: | Chemistry (Weinheim an Der Bergstrasse, Germany) |
| ISSN: | 1521-3765 0947-6539 |
| Popis: | Dearomatisation of indole derivatives to the corresponding isatin derivatives has been achieved with the aid of visible light and oxygen. It should be noted that isatin derivatives are highly important for the synthesis of pharmaceuticals and bioactive compounds. Notably, this chemistry works excellently with N‐protected and protection‐free indoles. Additionally, this methodology can also be applied to dearomatise pyrrole derivatives to generate cyclic imides in a single step. Later this methodology was applied for the synthesis of four pharmaceuticals and a pesticide called dianthalexin B. Detailed mechanistic studies revealed the actual role of oxygen and photocatalyst. Heterocycles: Dearomatisation of indole derivatives to the corresponding isatin derivatives has been achieved with the aid of visible light and oxygen. Additionally, this methodology can also be applied to dearomatise pyrrole derivatives to generate cyclic imides in a single step (see scheme). Detailed mechanistic studies revealed the actual role of oxygen and photocatalyst. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text