Cell migration in the postnatal subventricular zone
| Autor: | M.M. Fróes, Cecilia Hedin-Pereira, José Airton Alves, Mônica Marins, João R. L. Menezes |
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| Předmět: |
Postnatal neurogenesis
Physiology Rostral migratory stream Chain migration Immunology Biophysics Subventricular zone Radial glia Cell Communication Biology Biochemistry Cerebral Ventricles Neuroblast Cell Movement medicine Animals General Pharmacology Toxicology and Pharmaceutics lcsh:QH301-705.5 Gap junctions Neurons lcsh:R5-920 Chemotaxis Stem Cells General Neuroscience Neurogenesis Gap junction Cell Differentiation Cell migration Cell Biology General Medicine Anatomy Olfactory Bulb Olfactory bulb medicine.anatomical_structure Animals Newborn lcsh:Biology (General) nervous system Astrocytes Neuroglia lcsh:Medicine (General) Neuroscience Cell Division |
| Zdroj: | Scopus-Elsevier Brazilian Journal of Medical and Biological Research v.35 n.12 2002 Brazilian Journal of Medical and Biological Research Associação Brasileira de Divulgação Científica (ABDC) instacron:ABDC Brazilian Journal of Medical and Biological Research, Volume: 35, Issue: 12, Pages: 1411-1421, Published: DEC 2002 Brazilian Journal of Medical and Biological Research, Vol 35, Iss 12, Pp 1411-1421 (2002) |
| Popis: | New neurons are constantly added to the olfactory bulb of rodents from birth to adulthood. This accretion is not only dependent on sustained neurogenesis, but also on the migration of neuroblasts and immature neurons from the cortical and striatal subventricular zone (SVZ) to the olfactory bulb. Migration along this long tangential pathway, known as the rostral migratory stream (RMS), is in many ways opposite to the classical radial migration of immature neurons: it is faster, spans a longer distance, does not require radial glial guidance, and is not limited to postmitotic neurons. In recent years many molecules have been found to be expressed specifically in this pathway and to directly affect this migration. Soluble factors with inhibitory, attractive and inductive roles in migration have been described, as well as molecules mediating cell-to-cell and cell-substrate interactions. However, it is still unclear how the various molecules and cells interact to account for the special migratory behavior in the RMS. Here we will propose some candidate mechanisms for roles in initiating and stopping SVZ/RMS migration. |
| Databáze: | OpenAIRE |
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