Implications of Parasites Lacking Plasmodium falciparum Histidine-Rich Protein 2 on Malaria Morbidity and Control When Rapid Diagnostic Tests Are Used for Diagnosis
| Autor: | Alisha Chaudhry, Michelle L. Gatton, Sadmir Ciketic, Jane Cunningham, Qin Cheng, Jessica Dunn |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Plasmodium falciparum 030231 tropical medicine Protozoan Proteins Antigens Protozoan Malaria morbidity Kaplan-Meier Estimate Polymerase Chain Reaction 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Lactate dehydrogenase parasitic diseases medicine Animals Humans Immunology and Allergy Parasite hosting Malaria Falciparum Proportional Hazards Models Microscopy Rapid diagnostic test biology Diagnostic Tests Routine Transmission (medicine) business.industry Diagnostic test Models Theoretical equipment and supplies biology.organism_classification medicine.disease Virology Logistic Models 030104 developmental biology Infectious Diseases chemistry business Malaria |
| Zdroj: | The Journal of Infectious Diseases. 215:1156-1166 |
| ISSN: | 1537-6613 0022-1899 |
| DOI: | 10.1093/infdis/jix094 |
| Popis: | Background Rapid diagnostic tests (RDTs) are an important tool for malaria diagnosis, with most using antibodies against Plasmodium falciparum histidine-rich protein 2 (PfHRP2). Reports of P. falciparum lacking this protein are increasing, creating a problem for diagnosis of falciparum malaria in locations without quality-assured microscopy. Methods An agent-based stochastic simulation model of P. falciparum transmission was used to investigate the selective pressure exerted on parasite populations by use of RDTs for diagnosis of symptomatic cases. The model considered parasites with normal, reduced, or no PfHRP2, and diagnosis using PfHRP2-only or combination RDTs. Results Use of PfHRP2-only RDTs in communities where a PfHRP2-negative parasite was introduced during the simulation resulted in transmission of the parasite in >80% of cases, compared with |
| Databáze: | OpenAIRE |
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