Histoplasma Capsulatum Endocarditis Cured by Amphotericin B Combined with Surgery
| Autor: | W.E. Harston, Alice M. Savage, Robert H. Alford, Robert W. Bradsher, Curt G. Wickre |
|---|---|
| Rok vydání: | 1980 |
| Předmět: |
Adult
Male Pulmonary and Respiratory Medicine medicine.medical_specialty Pathology Histoplasma Critical Care and Intensive Care Medicine Histoplasmosis Immune system Aortic valve replacement Antigen Amphotericin B Coagulopathy medicine Humans Endocarditis Heart Failure biology business.industry Disseminated Intravascular Coagulation Middle Aged bacterial infections and mycoses medicine.disease biology.organism_classification Surgery Female Cardiology and Cardiovascular Medicine business medicine.drug |
| Zdroj: | Chest. 78:791-795 |
| ISSN: | 0012-3692 |
| Popis: | A patient is reported who had Histoplasma capsulatum endocarditis, a rare form of disseminated histoplasmosis. He also had disseminated intravascular coagulopathy and defects in cell-mediated immune responses to Histoplasma antigens. Prompt etiologic diagnosis was made by stain of tissue from a mouth ulcer and confirmed by culture of the organism from blood. An echocardiogram compared to a previous normal echocardiogram indicated changes consistent with a vegetation. Histologic examination of the resected valve demonstrated organisms. Amphotericin B administration (3.4 g) plus an aortic valve replacement resulted in cure. |
| Databáze: | OpenAIRE |
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