Comparison of the modified relative dose response (MRDR) and the relative dose response (RDR) in the assessment of vitamin A status in malnourished children
| Autor: | Dilip Mahalanabis, Mahbubur Rahman, Mohammed A. Wahed, Mohammad A. Khaled, Demissie Habte, J O Alvarez |
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| Rok vydání: | 1995 |
| Předmět: |
Male
Vitamin Pediatrics medicine.medical_specialty Serum retinol Nutritional Status Medicine (miscellaneous) Physiology Relative dose response chemistry.chemical_compound Humans Medicine Vitamin A Chromatography High Pressure Liquid Measurement method Nutrition and Dietetics Dose-Response Relationship Drug business.industry Vitamin A metabolism Retinol Infant Limiting Nutrition Disorders Retinol-Binding Proteins Retinol binding protein chemistry Child Preschool Female business |
| Zdroj: | The American Journal of Clinical Nutrition. 61:1253-1256 |
| ISSN: | 0002-9165 |
| DOI: | 10.1093/ajcn/61.6.1253 |
| Popis: | The modified-relative-dose-response (MRDR) test and the relative-dose-response (RDR) test were compared in 49 mildly to moderately malnourished Bangladeshi children. The MRDR test had a significantly lower sensitivity, detecting only 71% of children with very low serum retinol (or = 0.35 mumol/L) and 33% of children with low serum retinol (0.355-0.70 mumol/L) compared with 100% and 80% for the RDR test, respectively. The MRDR test showed a very strong dependency on retinol-binding protein (RBP) saturation (ie, percent saturation of RBP with retinol) compared with the RDR test. Only 3 (23%) of 13 children with RBP saturationor = 55% but low vitamin A stores were diagnosed as abnormal by the MRDR test. This suggests that when apo-RBP concentration is limiting, as it is in malnourished children, didehydroretinol, the analog used in the MRDR test cannot effectively compete with retinol for binding to apo-RBP. Under these circumstances, the MRDR test is rendered ineffective. The possibility of increasing the sensitivity of the test by using a high dose of didehydroretinol needs to be investigated. |
| Databáze: | OpenAIRE |
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