Prognostic molecular markers for motor recovery in acute hemorrhagic stroke: A systematic review
| Autor: | Simone Garcia Oliveira, Jean Alex Matos Ribeiro, Erika Shirley Moreira da Silva, Luisa Fernanda García-Salazar, Thiago Luiz Russo, Adriana Sanches Garcia-Araujo, Cássia Regina Saade-Pacheco, Ana Flávia Silveira |
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| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Poor prognosis business.industry Biochemistry (medical) Clinical Biochemistry MEDLINE General Medicine CINAHL Brain damage Recovery of Function Functional recovery medicine.disease Prognosis Biochemistry Stroke Hemorrhagic Stroke Data extraction Internal medicine medicine Humans Motor recovery medicine.symptom business Biomarkers |
| Zdroj: | Clinica chimica acta; international journal of clinical chemistry. 522 |
| ISSN: | 1873-3492 |
| Popis: | Background and aims Molecular biomarkers are associated with poor prognosis in ischemic stroke individuals. However, it might not be generalizable to post-acute hemorrhagic stroke since the underlying mechanisms of this brain damage differ from those found in ischemic stroke. The main purpose of this review was to synthesize the potential predictive molecular biomarkers for motor recovery following acute hemorrhagic stroke. Materials and methods An electronic search was conducted by 2 independent reviewers in the following databases: PubMed (Medline), EMBASE, Web of Science, and CINAHL. We included studies that addressed the following: collected blood, urine, or cerebrospinal fluid samples within 72 h after hemorrhagic stroke and that reported the prognostic association with functional motor recovery for each molecular biomarker. Screening of titles, abstracts, and full texts and data extraction were undertaken independently by pairs of reviewers. Results Twelve thousand, five hundred and sixty-four studies were identified and 218 were considered eligible. Finally, we included 70 studies, with 96 biomarkers analyzed, of which 61 were considered as independent prognostic biomarkers, and 10 presented controversial results. Conclusion This systematic review shows that motor functional recovery can be predicted by 61 independent prognostic molecular biomarkers assessed in the acute phase after a hemorrhagic stroke. |
| Databáze: | OpenAIRE |
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