Changes in Health-Related Quality of Life in Off-Pump Versus On-Pump Cardiac Surgery: Veterans Affairs Randomized On/Off Bypass Trial
| Autor: | Frederick L. Grover, Muath Bishawi, Joseph F. Collins, A. Laurie Shroyer, John A. Spertus, John S. Rumsfeld, Janet H. Baltz, Brack Hattler, Jacquelyn A. Quin, G. Hossein Almassi |
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| Rok vydání: | 2013 |
| Předmět: |
Graft Rejection
Male Pulmonary and Respiratory Medicine medicine.medical_specialty Randomization Hospitals Veterans Population Coronary Artery Bypass Off-Pump Patient characteristics Coronary Angiography Risk Assessment Severity of Illness Index Coronary Restenosis Angina Postoperative Complications Quality of life Humans Medicine Prospective Studies Coronary Artery Bypass education Veterans Affairs Aged Health related quality of life education.field_of_study Cardiopulmonary Bypass business.industry Graft Survival Coronary Stenosis Middle Aged medicine.disease United States Cardiac surgery Survival Rate Treatment Outcome Elective Surgical Procedures Quality of Life Physical therapy Surgery Cardiology and Cardiovascular Medicine business |
| Zdroj: | The Annals of Thoracic Surgery. 95:1946-1951 |
| ISSN: | 0003-4975 |
| Popis: | Background The relative benefits of performing coronary artery bypass graft surgery off-pump versus on-pump continue to be debated. A critical, patient-centered outcome is health-related quality of life; yet there has been limited evaluation in large-scale, multicenter trials of the off-pump versus on-pump impact upon quality of life. Methods The Veterans Affairs Randomized On/Off Bypass trial randomized 2,203 nonemergent patients to off-pump or on-pump from February 2002 to May 2007. Patients completed a general quality of life survey (VR-36) and a disease-specific quality of life survey, the Seattle Angina Questionnaire (SAQ), prior to surgery, then again at 3 and 12 months post-bypass. Results Of the 2,130 1-year survivors, 1,805 patients (85%) completed 1-year surveys. Randomization resulted in comparable baseline patient characteristics, including VR-36 and SAQ scores. At 3 months and 1-year post-procedure, there were no clinically relevant differences between off-pump and on-pump patients in any of the quality of life measures. Both groups had statistically significant, comparable improvements in the physical component scale of the VR-36, and in the SAQ scales. Conclusions For this trial's male, low-to-moderate risk, veteran population, there were no significant differences between off-pump and on-pump with regard to 1-year general and disease-specific quality of life outcomes. Both treatment arms experienced some improvements by 3 months, with continued improvements through 1-year post-bypass. |
| Databáze: | OpenAIRE |
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