Functional liver imaging with asialoglycoprotein receptors and serum hyaluronate in a patient with amyloidosis
| Autor: | Masaru Harada, Hirofumi Fukushima, Akihiro Iemura, Satoshi Itano, Kumi Imamura, Masahito Ohishi, Osamu Hashimoto, T. Ueno, Norito Matsukuma, Kyuichi Tanikawa, Masamichi Kojiro, Michio Sata |
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| Rok vydání: | 1995 |
| Předmět: |
Male
medicine.medical_specialty Pathology Amyloid Asialoglycoproteins Technetium Tc 99m Aggregated Albumin Liver Function Tests Internal medicine medicine Humans Hyaluronic Acid Radionuclide Imaging medicine.diagnostic_test business.industry Liver Diseases Amyloidosis Gastroenterology Middle Aged Hepatology Human serum albumin medicine.disease Magnetic Resonance Imaging medicine.anatomical_structure Hepatocyte Technetium Tc 99m Pentetate Asialoglycoprotein receptor business Liver function tests medicine.drug |
| Zdroj: | Journal of Gastroenterology. 30:403-407 |
| ISSN: | 1435-5922 0944-1174 |
| Popis: | A 47-year-old man with primary amyloidosis was admitted with abdominal pain. A new radionuclide liver imaging technique using Technetium-99 m diethylenetriamine-pentaacetic acid-galactosyl human serum albumin, was performed and the serum hyaluronate concentration was measured. Although ordinary laboratory tests revealed only slight abnormalities, the uptake of the radiolabelled ligand for hepatocyte asialo-glycoprotein receptors was dereased, and marked hepatomegaly was revealed. Furthermore, the serum hyaluronate level was elevated. Histological examination of a hepatic needle biopsy specimen revealed a marked deposition of amyloid in the hepatic perisinusoidal spaces. These results indicate, that this new radionuclide liver imaging technique (using Technetium-99 m diethylenetriamine-pentaacetic acid-galactosyl human serum albumin) and the measurement of serum hyaluronate may be useful supplementary tools for identifying amyloid deposition in the hepatic perisinusoidal spaces in patients with amyloidosis. |
| Databáze: | OpenAIRE |
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