An in vitro evaluation of the effect of laser irradiation on the thrombogenicity of thrombus
| Autor: | Sourav K. Kundu, Eberhard F. Mammen, Sarma Yellayi, J. Richard Spears, Linda P. McMath, Rajiv Patel, Tsunenori Ozawa |
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| Rok vydání: | 1992 |
| Předmět: |
medicine.medical_specialty
Antithrombin III Thrombogenicity In Vitro Techniques Fibrinogen law.invention Dogs Thrombin law hemic and lymphatic diseases medicine Animals cardiovascular diseases Irradiation Thrombus Whole blood Chemistry Lasers Thrombosis Hematology medicine.disease Laser Surgery Hemostasis cardiovascular system Peptide Hydrolases circulatory and respiratory physiology Biomedical engineering medicine.drug |
| Zdroj: | Thrombosis Research. 68:137-144 |
| ISSN: | 0049-3848 |
| Popis: | The effect of laser irradiation on the thrombogenicity of thrombus was evaluated by treating thrombi, formed in-vitro from canine blood, with two different doses of cw Nd:YAG laser energy at 1064 nm. The thrombi were then incubated with whole blood, and the plasma levels of fibrinogen and thrombin-antithrombin III-complexes were measured. A statistically significant decrease (p0.05) in the thrombogenicity was indicated by a reduction in both fibrinogen consumption and levels of thrombin-antithrombin III-complexes in the high dose group (600 joules, 100 degrees C peak temperature) in comparison to the low dose group (300 joules, 70 degrees C peak temperature) and the untreated thrombi. These findings suggest that laser irradiation of thrombus at an appropriate dose may substantially reduce its thrombogenicity and ability to modulate hemostasis. |
| Databáze: | OpenAIRE |
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