Plasma Neutrophil Gelatinase-Associated Lipocalin in Kidney Transplantation and Early Renal Function Prediction
| Autor: | O. Marie, Imad Abboud, Francine Bonnet, Samia Abbas, O. Semoun, Matthieu Resche-Rigon, Laurent Jacob, Marie-Reine Losser, Eric Bourgeois, Aurélien Bataille |
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| Rok vydání: | 2011 |
| Předmět: |
Adult
Male medicine.medical_specialty Time Factors medicine.medical_treatment Urology Delayed Graft Function Renal function Kidney Sensitivity and Specificity Lipocalin-2 Predictive Value of Tests Renal Dialysis Proto-Oncogene Proteins medicine Humans Prospective Studies Prospective cohort study Dialysis Kidney transplantation Transplantation business.industry Odds ratio Middle Aged medicine.disease Kidney Transplantation Lipocalins Surgery medicine.anatomical_structure Predictive value of tests Kidney Failure Chronic Female business Biomarkers Acute-Phase Proteins |
| Zdroj: | Transplantation. 92:1024-1030 |
| ISSN: | 0041-1337 |
| DOI: | 10.1097/tp.0b013e318230c079 |
| Popis: | BACKGROUND This prospective observational study aimed to assess the relevance of serial postoperative plasma neutrophil gelatinase-associated lipocalin (NGAL) measurements on prediction of early renal transplant function. METHODS Plasma NGAL (pNGAL) was measured (Triage NGAL Test; Biosite Inc., Inverness Medical) in 41 patients scheduled for kidney transplantation from deceased or living donors, immediately before and after surgery, and at 12 hr, day 1, day 3, and day 7. A delayed graft function (DGF) was defined as the need for dialysis during the first week. The results were expressed as median (Q1, Q3). RESULTS Of the 41 consecutive patients enrolled, all had a high preoperative pNGAL level: 453 ng/mL (382, 595). Fifteen (36.6%) presented a DGF. In patients with DGF, pNGAL was significantly higher at 12 hr (571 [467, 634] vs. 242 [158, 299] ng/mL, P |
| Databáze: | OpenAIRE |
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