Prognostic Significance of Serum PD-L1 Level in Patients with Locally Advanced or Metastatic Esophageal Squamous Cell Carcinoma Treated with Combination Cytotoxic Chemotherapy
| Autor: | Hui-Jie Li, Chuan-Qing Jing, Rong Fu, Xiu-Rong Li, Zhao-Feng Tan |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
PD-L1
0301 basic medicine Oncology medicine.medical_specialty medicine.medical_treatment Locally advanced clinical outcome chemotherapy 03 medical and health sciences 0302 clinical medicine Internal medicine mental disorders medicine In patient Original Research Chemotherapy biology business.industry Confounding Cytotoxic chemotherapy esophageal squamous cell carcinoma 030104 developmental biology Cancer Management and Research 030220 oncology & carcinogenesis biology.protein Biomarker (medicine) Immunohistochemistry prognosis business soluble PD-L1 |
| Zdroj: | Cancer Management and Research |
| ISSN: | 1179-1322 |
| DOI: | 10.2147/cmar.s312690 |
| Popis: | Rong Fu,1 Chuan-Qing Jing,1 Xiu-Rong Li,2 Zhao-Feng Tan,2 Hui-Jie Li2 1Clinical Department of Integrated Traditional Chinese and Western Medicine, The First Clinical Medical College of Shandong University of Traditional Chinese Medicine, Jinan, People’s Republic of China; 2Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, People’s Republic of ChinaCorrespondence: Hui-Jie Li Email 2008lihuijie@163.comBackground: There are no useful biomarkers for the clinical outcome of advanced esophageal squamous cell carcinoma (ESCC). In this study, we aimed to investigate the prognostic value of soluble PD-L1 (sPD-L1) in serum of patients with locally advanced or metastatic ESCC who received cytotoxic chemotherapy as first-line treatment.Materials and Methods: This study evaluated the expression pattern of PD-L1 by immunohistochemistry and sPD-L1 concentration, and correlation with clinicopathological factors and overall survival (OS) in 190 patients with ESCC.Results: sPD-L1 concentration was highly expressed in ESCC, especially in female patients. Patients with a high sPD-L1 level (≥ 0.63 ng/mL) had a shorter OS than those with a low sPD-L1 level (< 0.63 ng/mL). In a multivariate analysis, high sPD-L1 concentration remained an independent prognostic factor of OS after adjustment for possible confounders. However, tissue PD-L1 expression level was non-prognostic in this study.Conclusion: There was no significant correlation between serum sPD-L1 concentration and tissue PD-L1 expression level. sPD-L1 concentration before treatment could be an effective and convenient biomarker of prognosis in patients with locally advanced or metastatic ESCC treated with combination cytotoxic chemotherapy.Keywords: esophageal squamous cell carcinoma, PD-L1, soluble PD-L1, prognosis, clinical outcome, chemotherapy |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|