Advancement of the Infant Air-Jet Dry Powder Inhaler (DPI): Evaluation of Different Positive-Pressure Air Sources and Flow Rates
| Autor: | Mohammad A.M. Momin, Serena Bonasera, Michael Hindle, P. Worth Longest, Dale Farkas, Connor Howe |
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| Rok vydání: | 2021 |
| Předmět: |
Flow waveform
Chemistry Pharmaceutical Positive pressure Pharmaceutical Science Nose complex mixtures Article Excipients Administration Inhalation Humans Pharmacology (medical) Particle Size Lung Aerosolization Aerosols Pharmacology Organic Chemistry Infant Dry Powder Inhalers Equipment Design respiratory system Dry-powder inhaler Aerosol Volumetric flow rate Improved performance Dry powder Molecular Medicine Environmental science Powders Biotechnology Biomedical engineering |
| Zdroj: | Pharm Res |
| ISSN: | 1573-904X 0724-8741 |
| DOI: | 10.1007/s11095-021-03094-w |
| Popis: | PURPOSE: In order to improve the delivery of dry powder aerosol formulations to the lungs of infants, this study implemented an infant air-jet platform and explored the effects of different air sources, flow rates, and pulmonary mechanics on aerosolization performance and aerosol delivery through a preterm nose-throat (NT) in vitro model. METHODS: The infant air-jet platform was actuated with a positive-pressure air source that delivered the aerosol and provided a full inhalation breath. Three different air sources were developed to provide highly controllable positive-pressure air actuations (using actuation volumes of ~10 mL for the preterm model). While providing different flow waveform shapes, the three air sources were calibrated to produce the same flow rate magnitude (Q90: 90(th) percentile of flow rate). Multiple air-jet DPI designs were coupled with the air sources and evaluated with a model spray-dried excipient enhanced growth formulation. RESULTS: Compared to other designs, the D1-Single air-jet DPI provided improved performance with low variability across all three air sources. With the tested D1-Single air-jet and Timer air source, reducing the flow rate from 4 to 1.7 L/min marginally decreased the aerosol size and significantly increased the lung delivery efficiency above 50% of the loaded dose. These results were not impacted by the presence of downstream pulmonary mechanics (resistance and compliance model). CONCLUSIONS: The selected design was capable of providing an estimated >50% lung delivery efficiency of a model spray-dried formulation and was not influenced by the air source, thereby enabling greater flexibility for platform deployment in different environments. |
| Databáze: | OpenAIRE |
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