Effect of L-arginine on myoglobin-induced acute renal failure in the rabbit
| Autor: | R. Kikawada, Y. Wakabayashi |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
Male
medicine.medical_specialty Physiology Arginine Nitric oxide Renal Circulation chemistry.chemical_compound Internal medicine medicine Animals Cyclic GMP Nitrites Creatinine Renal circulation Nitrates business.industry Myoglobin Acute kidney injury Acute Kidney Injury medicine.disease Endocrinology medicine.anatomical_structure chemistry Renal blood flow Vascular resistance Vascular Resistance Rabbits medicine.symptom business Vasoconstriction |
| Zdroj: | The American journal of physiology. 270(5 Pt 2) |
| ISSN: | 0002-9513 |
| Popis: | Because myoglobin is a potent inhibitor of nitric oxide (NO), we tested whether myoglobin infusion results in renal vasoconstriction and dysfunction, on which L-arginine, a source of NO, has a protective effect in sedated, nondehydrated, and nonacidotic rabbits. The infusion of myoglobin (375 mg/kg) resulted in a decrease in renal blood flow, an increase in renal vascular resistance, and a decrease in creatine clearance associated with a decrease in urinary excretory rate of nitrite/nitrate and guanosine 3',5'-cyclic monophosphate (cGMP). These values 1-2 h after the infusion were significantly different from baseline levels. Co-administration of L-arginine (150 mg/kg bolus followed by 150 mg.kg(-1).min(-1) reversed these changes significantly with attenuation of urinary excretory rate of nitrite/nitrate and cGMP. This study suggests that the myoglobin-induced renal vasoconstriction and dysfunction and protective effect of L-arginine on these outcomes could be mediated through the NO system. |
| Databáze: | OpenAIRE |
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