Spotted fever diagnosis: Experience from a South Indian center
| Autor: | Verghese V p, Abhilash K Pp, Winsley Rose, Dumler Js, Prakash Jaj, Karthik Gunasekaran, Divyaa Elangovan, Susmitha Perumalla |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Scrub typhus Microbiology Serology Maculopapular rash medicine Humans Prospective Studies Prospective cohort study business.industry Public Health Environmental and Occupational Health General Medicine Petechial rash Spotted Fever Group Rickettsiosis medicine.disease Antibodies Bacterial Dermatology Rash Spotted fever Infectious Diseases Immunoglobulin M Scrub Typhus Macular Rash Parasitology medicine.symptom business Research Article |
| Zdroj: | Pathog Glob Health |
| ISSN: | 2047-7732 2047-7724 |
| DOI: | 10.1080/20477724.2021.1934293 |
| Popis: | Spotted fever (SF) is an important treatable cause of acute febrile illness (AFI) with rash and has reemerged in India. A prospective AFI with rash study was undertaken at a South Indian hospital to correlate specific clinical findings with laboratory confirmation of spotted fever. During the study period (December 2017 to May 2019), 175 patients with fever and rash were suspected to have spotted fever. Molecular assays for scrub typhus and spotted fever (47 kDa and ompA qPCR) and serology (IgM ELISA) was performed on the 96 individuals recruited. Laboratory confirmed SF cases (ompA qPCR positive) were 21, whereas laboratory supported SF cases (ompA negative but sero-positive by SF IgM ELISA) were 27. Among the 48 spotted fever (SF) cases, 70% of had maculopapular rash, 12.5% had macular rash, purpuric/petechial rash (severe rash) was seen in 8 patients (16.7%). Presence of rash on the palms and soles was associated with a relative risk (RR) of 4.36 (95% CI: 2.67–7.10; p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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