Association of Allelic Variants of the Reelin Gene with Autistic Spectrum Disorder: A Systematic Review and Meta-Analysis of Candidate Gene Association Studies
| Autor: | Cristina Carbonell, Antonio-Javier Chamorro, Ignacio Hernández-García, J.A. Mirón-Canelo, Miguel Marcos, Hugo Guillermo Ternavasio-de la Vega |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Male
Candidate gene Autism Spectrum Disorder Cell Adhesion Molecules Neuronal Health Toxicology and Mutagenesis lcsh:Medicine Nerve Tissue Proteins Biology Polymorphism Single Nucleotide polymorphism 03 medical and health sciences 0302 clinical medicine Polymorphism (computer science) 030225 pediatrics mental disorders reelin Humans Genetic Predisposition to Disease genetics Allele Child Gene Alleles Genetic Association Studies Genetic association Genetics Extracellular Matrix Proteins Brief Report Serine Endopeptidases autistic spectrum disorder lcsh:R Public Health Environmental and Occupational Health Odds ratio Genotype frequency meta-analysis Reelin Protein Meta-analysis Female 030217 neurology & neurosurgery |
| Zdroj: | International Journal of Environmental Research and Public Health, Vol 17, Iss 8010, p 8010 (2020) International Journal of Environmental Research and Public Health |
| ISSN: | 1661-7827 1660-4601 |
| Popis: | Autistic spectrum disorder (ASD) is a complex neurodevelopmental disability with a genetic basis, and several studies have suggested a potential role of the reelin gene (RELN) in ASD susceptibility. Accordingly, genetic association studies have explored this potential association, but the results have been controversial thus far. For this reason, we assessed the association of four genetic variants of RELN (the 5′UTR CGG triplet repeat and polymorphisms rs736707, rs362691, and rs2229864) with ASD by means of a systematic review and meta-analysis. We retrieved studies comparing the distribution of the above-mentioned genetic variants between ASD patients and healthy controls. A meta-analysis was conducted using a random effects model, and calculations of the odds ratios (ORs) and confidence intervals (CIs) were performed. A sensitivity analysis and tests to determine the heterogeneity of the results were also performed. Eleven previous studies fulfilled the inclusion criteria and analyzed the association of the above-mentioned genetic variants and ASD. We did not find any significant association between the allele or genotype frequencies of the analyzed polymorphisms and ASD, and large heterogeneity was found for the rs736707 polymorphism. Moreover, no significant differences were found between the 5′UTR triplet repeat and this disorder. In light of current evidence, no single genetic variant within this gene is clearly associated with the development of ASD, and ethnic differences may explain part of the observed heterogeneity. Larger studies among different ethnic groups are needed to establish the role of specific genetic variants within RELN in the etiology of this disorder. |
| Databáze: | OpenAIRE |
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