Corneal sensitivity and morphology of the corneal subbasal nerve plexus in primary congenital glaucoma
Autor: | Georgios Labiris, A.G. Schnaidt, Berthold Seitz, Zisis Gatzioufas, Bojan Pajic, Farhad Hafezi, Achim Langenbucher |
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Jazyk: | angličtina |
Rok vydání: | 2014 |
Předmět: |
Male
medicine.medical_specialty Adolescent genetic structures Glaucoma Ophthalmic Nerve Ophthalmic pathology Cornea Neuro-ophthalmology Corneal Sensitivity Ophthalmology medicine Humans Prospective Studies Child Microscopy Confocal business.industry Primary congenital glaucoma Nerve plexus medicine.disease eye diseases Ophthalmic nerve ddc:616.8 medicine.anatomical_structure Case-Control Studies Clinical Study Female sense organs business |
Zdroj: | Eye (London), Vol. 28, No 4 (2014) pp. 466-471 |
ISSN: | 0950-222X |
Popis: | To quantify the corneal subbasal nerve density and the total number of nerve fibers in primary congenital glaucoma (PCG) and to evaluate their impact on corneal sensitivity.Forty eyes of 26 PCG patients were compared with 40 eyes randomly selected from 40 non-glaucoma patients who populated the control group. Central corneal sensitivity (CCS) was assessed by means of Cochet-Bonnet esthesiometry. The mean subbasal nerve density and the total number of nerve fibers were quantified by laser-scanning confocal microscopy. Normality of data was assessed by Kolmogorov-Smirnov testing. Differences in parameters were assessed with Student's t-test, while correlations with CSS were assessed with Pearson's correlation.Significant differences were identified in the mean subbasal nerve density (2108 ± 692 μm in PCG, 2642 ± 484 μm in controls, P = 0.003) and in the total number of nerve fibers (12.3 ± 4.2 in PCG, 15.4 ± 3.1 in controls, P = 0.02). Both groups presented comparable mean CCS and tortuosity. Both groups presented strong correlations between CCS and mean nerve density (r = 0.57 in PCG, r = 0.67 in controls, all P0.05), and between CCS and total number of nerve fibers (r = 0.55 in PCG, r = 0.56 in controls, all P0.05).PCG exerts significant changes in both the mean subbasal nerve density and the total number of nerve fibers. However, these changes do not appear to affect central corneal sensitivity. |
Databáze: | OpenAIRE |
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