Chronic Pancreatitis: Evaluation of Pancreatic Exocrine Function with MR Pancreatography after Secretin Stimulation
| Autor: | Michel Cremer, Julien Stryuven, Celso Matos, Nicole Nicaise, Jacques Devière, Olivier Le Moine, Myriam Delhaye, Thierry Metens, Olivier Cappeliez |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
Adult
Male medicine.medical_specialty Pancreatic disease Adolescent Duodenum Stimulation Sensitivity and Specificity Gastroenterology Secretin Gastrointestinal Agents Pancreatic Juice Predictive Value of Tests Internal medicine Image Processing Computer-Assisted Odds Ratio medicine Humans Radiology Nuclear Medicine and imaging Pancreatic carcinoma Child Pancreas Aged Analysis of Variance medicine.diagnostic_test business.industry Maximal diameter Pancreatic Ducts Pancreatic Diseases Magnetic resonance imaging Middle Aged medicine.disease Magnetic Resonance Imaging Bicarbonates Logistic Models Pancreatitis Chronic Disease Female business hormones hormone substitutes and hormone antagonists Secretin test |
| Zdroj: | Europe PubMed Central |
| ISSN: | 1527-1315 0033-8419 |
| DOI: | 10.1148/radiology.215.2.r00ma10358 |
| Popis: | To compare duodenal filling seen at magnetic resonance (MR) pancreatography after secretin stimulation and biochemical parameters determined with the intraductal secretin test (IDST) for evaluation of pancreatic exocrine function.MR pancreatography after secretin stimulation and IDST were performed in 41 patients with chronic pancreatitis (group 1) and eight patients with other pancreatic disease (group 2). A control group (group 3, n = 28) underwent MR pancreatography after secretin stimulation only. MR pancreatograms were acquired before and every 30 seconds for 10 minutes after secretin injection. Duodenal filling was graded from least amount of filling (grade 1) to normal filling (grade 3) on the last MR pancreatogram. Pancreatic exocrine function was determined at IDST. Main pancreatic ductal diameter was compared between groups 1 and 3.All ductal diameters were significantly larger in group 1 (P.001). The maximal diameter variation after secretin stimulation was significantly higher in the control group (P =.001). Pancreatic exocrine function parameters determined at IDST were significantly lower in patients with grade 1 duodenal filling than in those with grade 2 or 3 (P.05). Maximal bicarbonate concentration alone was independently associated with all grades of duodenal filling (P =.007). The sensitivity and specificity of reduced duodenal filling for assessment of reduced pancreatic exocrine function were 72% and 87%, respectively.Duodenal filling grade determined at MR pancreatography after secretin stimulation allows specific estimation of pancreatic exocrine function. |
| Databáze: | OpenAIRE |
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