A 12-week, double-blind, placebo-controlled trial of galantamine adjunctive treatment to conventional antipsychotics for the cognitive impairments in chronic schizophrenia
| Autor: | Jung Goo Lee, Young Hoon Kim, Sae-Woom Lee, Bong Ju Lee |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
Adult
Male medicine.medical_specialty medicine.medical_treatment Verbal learning Cognition Double-Blind Method Internal medicine Brief Psychiatric Rating Scale medicine Galantamine Humans Pharmacology (medical) Psychiatry Antipsychotic Nootropic Agents Mini–Mental State Examination medicine.diagnostic_test Cognitive disorder Recognition Psychology Middle Aged medicine.disease Psychiatry and Mental health Treatment Outcome Schizophrenia Adjunctive treatment Chronic Disease Mental Recall Drug Therapy Combination Female Psychology Cognition Disorders Mental Status Schedule Color Perception medicine.drug Antipsychotic Agents |
| Zdroj: | International clinical psychopharmacology. 22(2) |
| ISSN: | 0268-1315 |
| Popis: | The objective of the study was to study the effects of acetylcholinesterase inhibitors on cognition in patients with schizophrenia. We conducted a 12-week, double-blind, placebo-controlled trial of galantamine as adjunctive treatment to conventional antipsychotic drugs on 24 patients with schizophrenia. The 24 patients had been stabilized on conventional antipsychotic drugs (chlorpromazine equivalent dose of 1390 mg/day) for a minimum of 3 months before their enrollment into the study. The patients were evaluated at baseline, and after 6 and 12 weeks using the Korean version of Mini Mental State Examination, Brief Psychiatric Rating Scale, and a standard neuropsychological battery. Compared with placebo, galantamine produced a small and nonsignificant change in the cognitive measures, but the score for recognition on the Rey Complex Figure Test improved significantly in patients given galantamine (P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|