Evaluation of oral maropitant as an antiemetic in cats receiving morphine and dexmedetomidine
| Autor: | Pati Kirch, Daniel M. Sakai, Manuel Martin-Flores, Alicia Mastrocco, Robin D. Gleed, Luis Campoy, McKenzie M Learn, Jordyn M. Boesch |
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| Rok vydání: | 2016 |
| Předmět: |
Quinuclidines
Vomiting 040301 veterinary sciences Nausea medicine.drug_class Ovariectomy Sedation Administration Oral Hysterectomy 0403 veterinary science chemistry.chemical_compound medicine Animals Antiemetic Retching Prospective Studies Dexmedetomidine Small Animals CATS Morphine business.industry 0402 animal and dairy science 04 agricultural and veterinary sciences Analgesics Non-Narcotic 040201 dairy & animal science Analgesics Opioid Treatment Outcome chemistry Anesthesia Cats Antiemetics Female medicine.symptom business Maropitant medicine.drug |
| Zdroj: | Journal of Feline Medicine and Surgery. 18:921-924 |
| ISSN: | 1532-2750 1098-612X |
| Popis: | Objectives The aim of the study was to evaluate the antiemetic effects of maropitant, after oral administration, in cats receiving morphine and dexmedetomidine. Methods This prospective, blinded, randomized controlled trial involved 98 healthy female domestic shorthair cats. Cats were randomly assigned to receive maropitant PO 8 mg total (group M) administered 18 h prior to sedation with intramuscular dexmedetomidine 20 µg/kg and morphine 0.1 mg/kg, or no antiemetic treatment (group C). The occurrence of signs of nausea (sialorrhea and lip-licking), retching and emesis during the 30 mins following administration of dexmedetomidine and morphine was measured for each group. Results Two cats were excluded from the investigation. Cats in group M (n = 46) received an average of 2.5 mg/kg of maropitant PO. Compared with group C (n = 50), cats in group M had lower incidences of emesis (M: 4% vs C: 40%), retching (M: 8% vs C: 40%) and lip-licking (M: 30% vs C: 52%) (all P Conclusions and relevance Maropitant 8 mg total PO was effective in reducing morphine and dexmedetomidine-induced emesis by 10-fold, when administered as early as 18 h in advance to healthy cats. Maropitant PO could be useful for administration the evening prior to a scheduled procedure requiring sedation/anesthesia to decrease the incidence of emesis. |
| Databáze: | OpenAIRE |
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