Recent Trends in Hypertension Genetics Research
| Autor: | Padma Tirunilai, Padma Gunda |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
0303 health sciences
medicine.medical_specialty business.industry Mortality rate Confounding Blood flow Disease 030204 cardiovascular system & hematology Essential hypertension medicine.disease 3. Good health 03 medical and health sciences 0302 clinical medicine Blood pressure Etiology Medicine Risk factor business Intensive care medicine 030304 developmental biology |
| Zdroj: | Genetics and Pathophysiology of Essential Hypertension |
| DOI: | 10.5772/31542 |
| Popis: | Human genome encompasses several thousands of genes which when fail to function normally lead to a defective phenotype expressed sometimes as a disease or disorder. These diseases or disorders may be simple or complex depending upon the nature and number of genes controlling the phenotypes and also their interaction with several other confounding demographic and environmental factors leading to a mosaic pattern of aetiology. Essential hypertension is one such common complex condition prevalent in most of the world populations and stands as a major risk factor for cardio-, cerebro and renovascular diseases (Kearney et al., 2005) adding to the mortality rate when the patients are not treated promptly and managed with proper surveillance. It also causes enormous financial burden to the patients and also nation’s economy. This necessitates the need to establish the causes with possible measures for prevention and cure of the condition especially in view of its high prevalence in several developed and developing countries. Research conducted especially in the past two decades were focused more on understanding the etiological factors including genetic components and their interaction with several other factors with a thrust to look for more appropriate therapeutic measures for essential hypertension (EHT). Regulation of blood pressure is important to maintain adequate blood flow in the body. By definition, blood pressure is the pressure of the blood flowing through the arteries. It depends on the flow of the blood pumped by the heart and the resistance exerted by the blood vessels against the flow. If the pressure is high, heart is forced to work harder. Based on the aetiology, hypertension is further grouped into two major groups viz., a) |
| Databáze: | OpenAIRE |
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