Evaluation of the corneal epithelium in non-Sjögren's and Sjögren's dry eyes: an in vivo confocal microscopy study using HRT III RCM

Autor: Anne G. Irvine, Tudor Tepelus, Srinivas R. Sadda, Gloria B. Chiu, Jianyan Huang, Olivia L Lee, Christopher J. Irvine
Rok vydání: 2018
Předmět:
0301 basic medicine
Adult
Male
medicine.medical_specialty
genetic structures
in vivo laser scanning confocal microscopy
In vivo confocal microscopy
Cell Count
Diagnostic Techniques
Ophthalmological
03 medical and health sciences
Basal (phylogenetics)
0302 clinical medicine
lcsh:Ophthalmology
Ophthalmology
medicine
Humans
Tomography
Optical
In patient
Corneal epithelium
Aged
corneal epithelium
Cellular density
Microscopy
Confocal
business.industry
Dry eye syndrome
Dry eyes
Epithelium
Corneal
General Medicine
Middle Aged
medicine.disease
eye diseases
030104 developmental biology
medicine.anatomical_structure
Sjogren's Syndrome
lcsh:RE1-994
Case-Control Studies
Sjögren’s syndrome
030221 ophthalmology & optometry
Dry Eye Syndromes
Female
sense organs
Sjogren s
Central cornea
business
Research Article
Zdroj: BMC Ophthalmology
BMC Ophthalmology, Vol 18, Iss 1, Pp 1-7 (2018)
ISSN: 1471-2415
Popis: Background The corneal epithelium is directly affected in dry eye syndrome. Thus, we attempted to describe the morphological features and evaluate the cellular density within the corneal epithelial layers in patients with non-Sjögren’s (NSDE) and Sjögren’s syndrome dry eyes (SSDE) by in vivo confocal microscopy (IVCM). Methods Central cornea was prospectively imaged by IVCM in 68 clinically diagnosed aqueous tear-deficient dry eyes and 10 healthy age-matched control eyes. Morphological characteristics of corneal epithelial layers and cellular densities were evaluated by four trained graders from the Doheny Eye Institute. Results Corneal epithelium in dry eyes presents morphological changes such as areas of enlarged and irregular shaped cells. In comparison with controls, the density of superficial epithelial cells was decreased in both the NSDE (P 0.05), but was lower in the SSDE group (P
Databáze: OpenAIRE
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