Curare blocks cationic conductance in artificial membranes containing hydrophobic proteins from cholinergic tissues
| Autor: | P. J. I. Salas, E. De Robertis, N. C. Adragna, Mario Parisi |
|---|---|
| Rok vydání: | 1975 |
| Předmět: |
animal structures
Heart Ventricles Lipoproteins Biophysics Nerve Tissue Proteins Biochemistry Diffusion medicine Animals Molecular Biology Electric Organ Chemistry Proteolipids Cationic polymerization Conductance Membranes Artificial Cell Biology Lipids Curare Kinetics Membrane Permeability (electromagnetism) Electrophorus Cats Potentiometry Cholinergic lipids (amino acids peptides and proteins) medicine.drug |
| Zdroj: | Biochemical and Biophysical Research Communications. 62:110-117 |
| ISSN: | 0006-291X |
| DOI: | 10.1016/s0006-291x(75)80412-8 |
| Popis: | Summary The permeability properties of control artificial lipidic membranes containing synthetic lipids were compared with those made with the lipids and hydrophobic proteins(i.e. proteolipids) extracted from electroplax of Electrophorus electricus and cat heart ventricle. While the controls did not show ionic selectivity the others showed a cationic conductance for Na + and K + giving rise to a diffusion potential, which was inhibited by 10 −4 Md-tubocurarine. It is suggested that proteolipids are responsible for this cationic conductance. |
| Databáze: | OpenAIRE |
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