Procaine Is Effective for Minimizing Postischemic Ventricular Fibrillation in Cardiac Surgery
| Autor: | Olav F.M. Sellevold, Einar M. Berg, Olaf W. Levang |
|---|---|
| Rok vydání: | 1995 |
| Předmět: |
Adult
Male medicine.medical_specialty Lidocaine Procaine Hydrochloride Fentanyl Procaine Double-Blind Method Internal medicine medicine Humans Aspartate Aminotransferases Coronary Artery Bypass Aged Fibrillation L-Lactate Dehydrogenase business.industry Hemodynamics Alanine Transaminase Arrhythmias Cardiac Middle Aged medicine.disease Cardiac surgery Anesthesiology and Pain Medicine Isoflurane Anesthesia Reperfusion Injury Ventricular fibrillation Ventricular Fibrillation Cardiology Female medicine.symptom business medicine.drug |
| Zdroj: | Anesthesia & Analgesia. 81:932-938 |
| ISSN: | 0003-2999 |
| Popis: | Procaine hydrochloride was added to cardioplegia and studied for its efficacy in stabilizing the postischemic rhythm after aortic declamping in cardiac surgery. Fifty-six patients scheduled for coronary artery bypass grafting (CABG), were included in a randomized, double-blind study. The patients were anesthetized with isoflurane, low-dose fentanyl, diazepam, and pancuronium. In the study group (28 patients), St. Thomas’ Hospital cardioplegic solution II (Plegisol@) was prepared with 1 mM procaine. The control group (28 patients) was given the same cardioplegia with saline. Ventricular fibrillation (VF) occurring after declamping was treated with direct current (DC) shock (g-12-12-20 J). There were no significant differences with regard to demographic properties or anesthesiologic and surgical treatment. Two patients (7%) in the procaine group required DC shock for VF, compared to 28 (100%) in the control group (P < 0.001). The amount of lidocaine (mean 2 SEM) given for resistant dysrhythmias was 3.6 mg 2 3.6 in the procaine group compared to 35.7 mg 5 9.2 in the control group (P < 0.002). One patient in each group required temporary pacing. The number of synchronized DC shocks for conversion of atria1 fibrillation was lower in the procaine group (P < 0.05). The enzyme release the first day after surgery was lower in the procaine group (P < 0.05). Procaine (1 mM) in cardioplegia stabilizes the postischemic rhythm in CABG surgery in humans without any observed adverse effects. |
| Databáze: | OpenAIRE |
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