Salvia hispanica L. (chia) seeds oil extracts reduce lipid accumulation and produce stress resistance in Caenorhabditis elegans
| Autor: | Juliana Cristina Veit, Cristiane Casagrande Dernadin, Matheus Chimelo Bianchini, Willian Goulart Salgueiro, Tatiana Emanuelli, Cristiane de Freitas Rodrigues, Robson Luiz Puntel, Daiana Silva Ávila |
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| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Antioxidant Salvia hispanica Endocrinology Diabetes and Metabolism medicine.medical_treatment Medicine (miscellaneous) lcsh:TX341-641 03 medical and health sciences chemistry.chemical_compound C. elegans Salvia hispanica and chia Lipids food medicine Food science Antidote lcsh:RC620-627 Caenorhabditis elegans chemistry.chemical_classification 030109 nutrition & dietetics Nutrition and Dietetics biology Cholesterol Research Lipid metabolism biology.organism_classification food.food lcsh:Nutritional diseases. Deficiency diseases 030104 developmental biology Nematode chemistry lcsh:Nutrition. Foods and food supply Polyunsaturated fatty acid |
| Zdroj: | Nutrition & metabolism, 15:83 Nutrition & Metabolism Nutrition & Metabolism, Vol 15, Iss 1, Pp 1-9 (2018) |
| Popis: | Background Salvia hispanica seeds have been commonly used by people that seek healthy habits through natural foods to reduce cholesterol and triacylglycerides levels, however, the evidences that support this assumption are still scarce in literature. Here, we aimed to evaluate the lipid lowering effects of chia by using Caenorhabditis elegans as animal model, a nematode that has proven its usefulness for lipid metabolism studies. Methods We prepared hexane (HE) and Bligh-Dyer (BDE) extracts, evaluated and compared their safety, antioxidant potential and their lipid-lowering activity in the worms. Results The characterization of both extracts demonstrated that there were no differences in their lipid composition; however, BDE depicted better antioxidant potential. Both extracts reduced worm’s survival from 2%, and reproduction was reduced following treatment with both extracts, though a more notable effect was observed in HE-treated worms. In addition, the non-toxic concentration of both extracts (1%) increased stress resistance against paraquat toxicity in an antidote paradigm. Notably, this same concentration of both extracts reduced lipid accumulation in obese worms, which was not caused by food deprivation. Conclusions Taken together, our data demonstrate that both extraction methods from chia seeds result in oils that are rich in mono and polyunsaturated fatty acids, which may modulate lipid accumulation and provide antioxidant resistance in C. elegans. |
| Databáze: | OpenAIRE |
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