Effect of intramyocardial delivery of autologous bone marrow mononuclear stem cells on the regional myocardial perfusion
| Autor: | Rayyan Hemetsberger, Mariann Gyöngyösi, Aliasghar Khorsand, Dietmar Glogar, Silvia Charwat, Markus Dettke, Gerald Maurer, Irene Lang, Senta Graf, Noemi Nyolczas, Sholeh Zamini, Heinz Sochor |
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| Rok vydání: | 2010 |
| Předmět: |
Adult
Male Randomization Myocardial Infarction Myocardial Reperfusion Transplantation Autologous medicine Humans Myocardial infarction Bone Marrow Transplantation Ejection fraction business.industry Myocardium Stroke Volume Hematology Stroke volume Middle Aged Autologous bone medicine.disease Treatment Outcome medicine.anatomical_structure Female Bone marrow Stem cell Nuclear medicine business Perfusion Stem Cell Transplantation |
| Zdroj: | Thrombosis and Haemostasis. 103:564-571 |
| ISSN: | 2567-689X 0340-6245 |
| DOI: | 10.1160/th09-08-0520 |
| Popis: | SummaryThe aim of the sub-study of the MYSTAR randomised trial was to analyse the changes in myocardial perfusion in NOGA-defined regions of interest (ROI) with intramyocardial injections of autologous bone marrow mononuclear cells (BM-MNC) using an elaborated transformation algorithm. Patients with recent first acute myocardial infarction (AMI) and left ventricular (LV) ejection fraction (EF) between 30–45% received BM-MNC by intramyocardial followed by intracoronary injection 68 ± 34 days post-AMI (pooled data of MYSTAR). NOGA-guided endocardial mapping and 99m-Sestamibi-SPECT (single photon emission computer tomography) were performed at baseline and at three months follow-up (FUP). ROI was delineated as a best polygon by connecting of injection points of NOGA polar maps. ROIs were projected onto baseline and FUP polar maps of SPECT calculating the perfusion severity of ROI. Infarct size was decreased (from 27.2 ± 10.7% to 24.1 ± 11.5%, pClinical Trials Gov Nr: NCT00384982. |
| Databáze: | OpenAIRE |
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