How electrically evoked compound action potentials in chronically implanted guinea pigs relate to auditory nerve health and electrode impedance
| Autor: | Andrew M Rabah, Kara C. Schvartz-Leyzac, Christopher J. Buswinka, Deborah J. Colesa, Yehoash Raphael, Donald L. Swiderski, Bryan E. Pfingst |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Materials science Acoustics and Ultrasonics medicine.medical_treatment Guinea Pigs Action Potentials Stimulus (physiology) Deafness Cell size 03 medical and health sciences 0302 clinical medicine Arts and Humanities (miscellaneous) Cochlear implant medicine Electrode array otorhinolaryngologic diseases Electric Impedance Animals Cochlear Nerve Spiral ganglion Evoked compound action potential Electrode impedance Psychological and Physiological Acoustics Cochlear Implantation Electric Stimulation 030104 developmental biology medicine.anatomical_structure Amplitude Cochlear Implants Evoked Potentials Auditory sense organs 030217 neurology & neurosurgery Biomedical engineering |
| Zdroj: | J Acoust Soc Am |
| Popis: | This study examined how multiple measures based on the electrically evoked compound action potential (ECAP) amplitude-growth functions (AGFs) were related to estimates of neural [spiral ganglion neuron (SGN) density and cell size] and electrode impedance measures in 34 specific pathogen free pigmented guinea pigs that were chronically implanted (4.9–15.4 months) with a cochlear implant electrode array. Two interphase gaps (IPGs) were used for the biphasic pulses and the effect of the IPG on each ECAP measure was measured (“IPG effect”). When using a stimulus with a constant IPG, SGN density was related to the across-subject variance in ECAP AGF linear slope, peak amplitude, and N1 latency. The SGN density values also help to explain a significant proportion of variance in the IPG effect for AGF linear slope and peak amplitude measures. Regression modeling revealed that SGN density was the primary dependent variable contributing to across-subject variance for ECAP measures; SGN cell size did not significantly improve the fitting of the model. Results showed that simple impedance measures were weakly related to most ECAP measures but did not typically improve the fit of the regression model. |
| Databáze: | OpenAIRE |
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