Structure–function relationship in ocular hypertension and glaucoma: interindividual and interocular analysis by OCT and pattern ERG
| Autor: | Tommaso Salgarello, L. Montrone, Stefania Aliberti, A. Colotto, G. Stifano, Emilio Balestrazzi, Benedetto Falsini, Dario Marangoni, Francesca Campagna |
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| Přispěvatelé: | Falsini, Benedetto, Marangoni, D, Salgarello, Tommaso, Stifano, Giovanna, Montrone, Lucrezia, Campagna, Francesca, Aliberti, Stefania, Balestrazzi, Emilio, Colotto, Alberto |
| Rok vydání: | 2008 |
| Předmět: |
Male
Retinal Ganglion Cells medicine.medical_specialty genetic structures Optic Disk Nerve fiber layer Glaucoma Ocular hypertension Retinal ganglion Cellular and Molecular Neuroscience chemistry.chemical_compound Nerve Fibers Optical coherence tomography Ophthalmology Optic Nerve Diseases Electroretinography medicine Humans medicine.diagnostic_test business.industry Retinal Middle Aged medicine.disease eye diseases Sensory Systems medicine.anatomical_structure Pattern Recognition Visual chemistry Optic nerve Female Ocular Hypertension sense organs business Glaucoma Open-Angle Tomography Optical Coherence |
| Zdroj: | Graefe's Archive for Clinical and Experimental Ophthalmology. 246:1153-1162 |
| ISSN: | 1435-702X 0721-832X |
| DOI: | 10.1007/s00417-008-0808-5 |
| Popis: | BACKGROUND: Pattern electroretinogram (PERG) and optical coherence tomography (OCT) represent objective probes to investigate respectively the function of retinal ganglion cells and their structure as retinal nerve fiber layer (RNFL) thickness. We examined interindividual (II) correlations of PERG amplitude and RNFL thickness, as well as correlations between interocular (IO) differences in both measures, in ocular hypertension (OHT) and early glaucoma (EG) patients. METHODS: Thirty-one OHT, 34 EG (mean deviation: -1 to -6 dB) and 16 age-matched controls were examined in both eyes. Participants had clear optical media, no or moderate refractive errors and no concomitant ocular or systemic diseases. PERGs were elicited by counterphased (16.28 reversals/second) gratings (1.6 cycles/degree spatial frequency). The Fourier isolated 2nd harmonic PERG amplitude and phase were measured. RNFL thickness was quantified by means of OCT Stratus according to a standard protocol. Average, superior and inferior RNFL thicknesses were considered. RESULTS: Mean PERG amplitude was decreased (p < 0.01) in both OHT and EG patients compared to controls. Mean RNFL thicknesses were reduced (p < 0.01) in EG patients compared to both OHT and controls. In OHT patients, PERG amplitude did not correlate significantly with RNFL thickness in both II and IO analysis. In EG patients, PERG amplitude was positively correlated with RNFL thickness in both II (p < 0.005) and IO (p < 0.001) analysis. The slope of the correlation predicted that PERG losses exceeded systematically RNFL losses when the latter were between 0 and -0.25 log units. CONCLUSIONS: Both II and IO analyses revealed a lack of structure-function relationship in OHT, suggesting that, at this disease stage, PERG losses appear to affect primarily retinal/optic nerve head function. In EG they reflect both dysfunction and RNFL loss. |
| Databáze: | OpenAIRE |
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