Alcohol Attenuates Activation in the Bilateral Anterior Insula during an Emotional Processing Task: A Pilot Study †
| Autor: | Martin P. Paulus, Claudia B. Padula, Scott C. Matthews, Shannon K. Robinson, Alan N. Simmons, Marc A. Schuckit, Susan F. Tapert |
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| Rok vydání: | 2011 |
| Předmět: |
Adult
Male Emotions Pilot Projects Alcohol Placebo Placebos Young Adult chemistry.chemical_compound medicine Humans Ingestion Young adult Cerebral Cortex Psychiatric Status Rating Scales Social stress Cognitive Aspects Facial expression Ethanol medicine.diagnostic_test Central Nervous System Depressants General Medicine Facial Expression Oxygen Breath Tests chemistry Anesthesia Female Functional magnetic resonance imaging Psychology Software |
| Zdroj: | Alcohol and Alcoholism. 46:547-552 |
| ISSN: | 1464-3502 0735-0414 |
| Popis: | Aims: Alcohol acutely reduces agitation and is widely used in social situations, but the neural substrates of emotion processing during its intoxication are not well understood. We examine whether alcohol's social stress dampening effect may be via reduced activity in the cortical systems that subserve awareness of bodily sensations, and are associated with affective distress. Methods: Blood oxygen level-dependent activation was measured through 24 functional magnetic resonance imaging sessions in 12 healthy volunteers during an emotional face-processing task following ingestion of a moderate dose of alcohol and a placebo beverage. Results: Results revealed that bilateral anterior insula response to emotional faces was significantly attenuated following consumption of alcohol, when compared with placebo (clusters >1472 μl; corrected P |
| Databáze: | OpenAIRE |
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