An Under-Appreciated Source of Reproducibility Issues in Cross-Coupling: Solid-State Decomposition of Primary Sodium Alkoxides in Air
| Autor: | Robert Wethman, Keary M. Engle, Joseph Derosa, Van T. Tran, Steven R. Wisniewski, Omar Apolinar, Taeho Kang, John R. Coombs, Roman Kleinmans, Anuji Abraham |
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| Rok vydání: | 2020 |
| Předmět: |
Solid-state chemistry
Primary (chemistry) Materials science Sodium Chemical process of decomposition Kinetics Inorganic chemistry chemistry.chemical_element General Chemistry Decomposition Catalysis symbols.namesake chemistry.chemical_compound Nickel chemistry Alkoxide symbols Raman spectroscopy Palladium |
| Zdroj: | ACS Catalysis. 11:502-508 |
| ISSN: | 2155-5435 |
| Popis: | The decomposition of primary sodium alkoxide salts under ambient storage conditions and the effects of this phenomenon on commonly employed transition-metal-catalyzed cross-coupling reactions are described. By utilizing NMR, IR, and Raman spectroscopy, along with a modified Karl Fischer analysis, the main inorganic degradants were characterized, and CO2 in the air was found to be a critical reactant within the decomposition process. The effects of storage conditions on decomposition were evaluated, and the preliminary experiments to understand the kinetics of this process were performed. |
| Databáze: | OpenAIRE |
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