Açaí berries (Euterpe oleracea Mart.) dried extract improves ethanol-induced ulcer in rats
| Autor: | Thaise Boeing, Luiz Carlos Klein-Júnior, Luísa Nathália Bolda Mariano, Benhur Judah Cury, Eduardo Breviglieri, Priscila de Souza, Sérgio Faloni de Andrade, Lincon Bordignon Somensi, Luisa Mota da Silva |
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| Rok vydání: | 2020 |
| Předmět: |
Antioxidant
Euterpe 030309 nutrition & dietetics DPPH medicine.medical_treatment Pharmaceutical Science 01 natural sciences Antioxidants Inhibitory Concentration 50 03 medical and health sciences chemistry.chemical_compound Nutraceutical In vivo Gastric mucosa medicine Animals Stomach Ulcer Rats Wistar Inflammation Pharmacology 0303 health sciences Dose-Response Relationship Drug Ethanol Traditional medicine biology Plant Extracts Superoxide Dismutase 010401 analytical chemistry Free Radical Scavengers Glutathione Anti-Ulcer Agents biology.organism_classification Rats 0104 chemical sciences Disease Models Animal medicine.anatomical_structure chemistry Female Acai Berries |
| Zdroj: | Journal of Pharmacy and Pharmacology. 72:1239-1244 |
| ISSN: | 2042-7158 0022-3573 |
| Popis: | Objectives Açaí (Euterpe oleracea) is widely consumed in Brazil and known for its numerous health-beneficial properties. This study investigated the gastroprotective potential of the dried açaí berries extract (DAE). Methods Dried açaí berries extract effect was evaluated against ethanol-induced gastric ulcer in rats. Its ability to regulate antioxidant defenses and reduce inflammatory parameters was evaluated in the ulcerated tissues. The scavenger capability of DAE was assessed by DPPH assay, and phytochemical composition was accessed by UHPLC. Key findings The extract showed radical scavenger activity in vitro (IC50 = 210 µg/ml) and gastroprotective effect in vivo, reducing the ulcerated area by 83%, 67% and 48% at doses of 30 and 100 mg/kg (p.o) and 3 mg/kg (i.p), respectively, compared with vehicle group. Besides, DAE (100 mg/kg, p.o) increased the GSH content and GST activity in ulcerated mucosa. Animals treated with DAE showed normalized levels of SOD activity, elevated CAT activity and decreased MPO activity, as well as reduced TNF-α levels, compared with vehicle group. Peonidin-3-glucoside, peonidin-3-rutinoside, cyanidin-3,5-hexoside-pentoside, cyaniding-3-glucoside, pelargonidin-3-glucoside and pelargonidin-3-rutinoside were identified in DAE. Conclusions Our findings suggest that DAE reduces the inflammation and maintains the oxidative balance of gastric mucosa, therefore being a promising natural resource or useful nutraceutical to protect gastric mucosa. |
| Databáze: | OpenAIRE |
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