Studies of the control of thyroid function in endemic goiter in Eastern New Guinea
| Autor: | M. L. Black, Brian F. Good, Maurice L. Wellby, M. J. Hoffmann, I. H. Buttfield, E. K. Mason, Basil S. Hetzel |
|---|---|
| Rok vydání: | 1966 |
| Předmět: |
medicine.medical_specialty
Goiter Endocrinology Diabetes and Metabolism Clinical Biochemistry Thyroid Gland chemistry.chemical_element Thyrotropin Urine Thyroid Function Tests Iodine Biochemistry Thyroid function tests Iodine Radioisotopes Endocrinology Internal medicine Medicine Humans New Guinea medicine.diagnostic_test business.industry Biochemistry (medical) Thyroid New guinea Iodized Oil medicine.disease Iodine deficiency medicine.anatomical_structure chemistry Triiodothyronine Thyroid function business |
| Zdroj: | The Journal of clinical endocrinology and metabolism. 26(11) |
| ISSN: | 0021-972X |
| Popis: | Studies of the control of thyroid function in endemic goiter have been carried out in the rugged mountainous Huon Peninsula of Eastern New Guinea, where there is severe iodine deficiency. In 91 natives living in the endemic area the mean urinary iodine was 12 ± 12 μg/day compared with 49 ± 55 in 31 coastal natives. Observations on 131I uptake in native villages with portable equipment revealed a higher 24-hr 131I uptake in 59 goitrous natives (77 ± 13 %) than in 122 nongoitrous natives (67 ± 20 %). The serum PBI was lower in 85 goitrous natives (2.9 ± 1.7) than in 119 nongoitrous natives (4.9 ± 2.0). The T3 resin uptake was also lower in 80 goitrous natives (86 ± 15) than in 115 nongoitrous (94 ± 18). Serum TSH levels estimated using the McKenzie method revealed a significant elevation in goitrous but not in nongoitrous natives. Administration of T3 in a dosage of 120 μg daily to 6 natives for 5 days was followed by a fall in 24-hr 131I uptake from 81 to 41 %. Observations in 43 natives who had received i... |
| Databáze: | OpenAIRE |
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