Association of low birth weight with cardiometabolic diseases in Swedish twins: a population-based cohort study
Autor: | Ruixue Song, Hui Xu, Xuerui Li, Wenzhe Yang, Rongrong Yang, Weili Xu, Xiuying Qi |
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Rok vydání: | 2021 |
Předmět: |
Adult
medicine.medical_specialty Epidemiology Population 030204 cardiovascular system & hematology Gee Cohort Studies 03 medical and health sciences 0302 clinical medicine Risk Factors adult cardiology Medicine Birth Weight Humans 030212 general & internal medicine education 2. Zero hunger Sweden education.field_of_study business.industry Medical record Public health general diabetes public health Infant Newborn General Medicine Infant Low Birth Weight Middle Aged Twin study Stroke Low birth weight Diabetes Mellitus Type 2 medicine.symptom business Body mass index Demography |
Zdroj: | BMJ Open BMJ Open, Vol 11, Iss 6 (2021) |
ISSN: | 2044-6055 |
Popis: | ObjectivesTo examine the association between low birth weight (LBW) and cardiometabolic diseases (CMDs, including heart disease, stroke and type 2 diabetes mellitus) in adulthood, and to explore whether genetic, early-life environmental and healthy lifestyle factors play a role in this association.DesignA population-based twin study.SettingTwins from the Swedish Twin Registry who were born in 1958 or earlier participated in the Screening Across the Lifespan Twin (SALT) study for a full-scale screening during 1998–2002 and were followed up until 2014.Participants19 779 twin individuals in Sweden with birthweight data available (mean age: 55.45 years).Primary and secondary outcome measuresCMDs were assessed based on self-reported medical records, medication use and records from the National Patient Registry. A lifestyle index encompassing smoking status, alcohol consumption, exercise levels and Body Mass Index was derived from the SALT survey and categorised as unfavourable, intermediate or favourable. Data were analysed using generalised estimating equation (GEE) models and conditional logistic regression models.ResultsOf all participants, 3998 (20.2%) had LBW and 5335 (27.0%) had incident CMDs (mean age at onset: 63.64±13.26 years). In GEE models, the OR of any CMD was 1.39 (95% CI 1.27 to 1.52) for LBW. In conditional logistic regression models, the LBW–CMD association became non-significant (OR=1.21, 95% CI 0.94 to 1.56). The difference in ORs from the two models was statistically significant (pConclusionLBW is associated with an increased risk of adult CMDs, and genetic and early-life environmental factors may account for this association. However, a favourable lifestyle profile may modify this risk. |
Databáze: | OpenAIRE |
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