Mortality hazard and survival after tuberculosis treatment
| Autor: | Sharon Sharnprapai, Dolly J. Katz, Fernando A. Wilson, Thaddeus L. Miller, Stephen E. Weis, Suzanne F. Beavers, Melissa Pagaoa, Jenny W.Y. Pang, Sally Hoger |
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| Rok vydání: | 2015 |
| Předmět: |
Adult
Male medicine.medical_specialty Tuberculosis Time Factors genetic structures Adolescent Research and Practice HIV Infections Disease National Death Index Young Adult Latent Tuberculosis Risk Factors Internal medicine Cause of Death medicine Humans Survivors Young adult Cause of death Aged Retrospective Studies business.industry Mortality rate Racial Groups Public Health Environmental and Occupational Health Retrospective cohort study social sciences Middle Aged medicine.disease humanities United States Surgery Vital Status population characteristics Female Centers for Disease Control and Prevention U.S business human activities |
| Zdroj: | American journal of public health. 105(5) |
| ISSN: | 1541-0048 |
| Popis: | Objectives. We compared mortality among tuberculosis (TB) survivors and a similar population. Methods. We used local health authority records from 3 US sites to identify 3853 persons who completed adequate treatment of TB and 7282 individuals diagnosed with latent TB infection 1993 to 2002. We then retrospectively observed mortality after 6 to 16 years of observation. We ascertained vital status as of December 31, 2008, using the Centers for Disease Control and Prevention’s National Death Index. We analyzed mortality rates, hazards, and associations using Cox regression. Results. We traced 11 135 individuals over 119 772 person-years of observation. We found more all-cause deaths (20.7% vs 3.1%) among posttreatment TB patients than among the comparison group, an adjusted average excess of 7.6 deaths per 1000 person-years (8.8 vs 1.2; P Conclusions. Fully treated TB is still associated with substantial mortality risk. Cure as currently understood may be insufficient protection against TB-associated mortality in the years after treatment, and TB prevention may be a valuable opportunity to modify this risk. |
| Databáze: | OpenAIRE |
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