Cytokine Gene Expression During Infeetion of Miee Lacking CD4 and/or CD8 with Trypanosoma cruzi
| Autor: | Anders Örn, Martin E. Rottenberg, L. Sporrong, Hans Wigzell, I. Persson |
|---|---|
| Rok vydání: | 1995 |
| Předmět: |
Chagas disease
CD8 Antigens T cell Immunology Biology Lymphocyte Activation Nitric Oxide Polymerase Chain Reaction Nitric oxide Mice chemistry.chemical_compound parasitic diseases medicine Animals Chagas Disease Trypanosoma cruzi Cells Cultured Messenger RNA Lymphokine General Medicine biology.organism_classification medicine.disease Molecular biology Mice Mutant Strains Nitric oxide synthase medicine.anatomical_structure Gene Expression Regulation chemistry CD4 Antigens biology.protein Cytokines Disease Susceptibility CD8 |
| Zdroj: | Scandinavian Journal of Immunology. 41:164-170 |
| ISSN: | 1365-3083 0300-9475 |
| DOI: | 10.1111/j.1365-3083.1995.tb03549.x |
| Popis: | The expression of lymphokine genes during infection of virulent (Tulahuén) or mild (CA-I) strains of T. cruzi was studied in mice lacking CD4 and/or CD8 molecules. The increased susceptibility of CD4- and CD4-CD8- mice to infection with CA-I or Tulahuén was parallelled by diminished IFN-gamma mRNA levels. Nitric oxide release and inducible nitric oxide synthase mRNA accumulation by cells from Tulahuén infected CD4- mice was also diminished. CD8- (but not CD4-CD8- mice) showed an increased IL-4 and IL-10 mRNA accumulation upon infection with both strains of T. cruzi. A 'Th2-like' response (higher IL-4 and IL-10 mRNA to IFN-gamma mRNA ratio), was also observed when cells from noninfected CD8- mice were stimulated with T cell mitogens. |
| Databáze: | OpenAIRE |
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