SR1, a Mouse Odorant Receptor with an Unusually Broad Response Profile
| Autor: | Hiroaki Matsunami, Xavier Grosmaitre, Peter Mombaerts, Minghong Ma, Stefan H. Fuss, Anderson C. Lee, Kaylin A. Adipietro |
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| Rok vydání: | 2009 |
| Předmět: |
Male
Models Neurological Sensory system Olfaction Biology Receptors Odorant Article Mice Consensus Sequence Reaction Time medicine Consensus sequence Animals Coding region Receptor Genetics General Neuroscience Gene targeting Mice Mutant Strains Cell biology Mice Inbred C57BL Smell medicine.anatomical_structure Gene Targeting Female Heterologous expression Olfactory epithelium |
| Zdroj: | The Journal of Neuroscience. 29:14545-14552 |
| ISSN: | 1529-2401 0270-6474 |
| DOI: | 10.1523/jneurosci.2752-09.2009 |
| Popis: | The current consensus model in mammalian olfaction is that the detection of millions of odorants requires a large number of odorant receptors (ORs) and that each OR interacts selectively with a small subset of odorants, which are typically related in structure. Here, we report the odorant response properties of an OR that deviates from this model: SR1, a mouse OR that is abundantly expressed in sensory neurons of the septal organ and also of the main olfactory epithelium. Patch-clamp recordings reveal that olfactory sensory neurons (OSNs) that express SR1 respond to many, structurally unrelated odorants, and over a wide concentration range. Most OSNs expressing a gene-targeted SR1 locus that lacks the SR1 coding sequence do not show this broad responsiveness. Gene transfer in the heterologous expression system Hana3A confirms the broad response profile of SR1. There may be other mouse ORs with such broad response profiles. |
| Databáze: | OpenAIRE |
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