Prevalence of hepatitis C virus infection in thalassemia and haemodialysis patients in north Iran-Rasht
| Autor: | Malek Moien Ansar, A. Kooloobandi |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
Adult
Male medicine.medical_specialty Blood transfusion Thalassemia Hepatitis C virus medicine.medical_treatment Population Enzyme-Linked Immunosorbent Assay Hepacivirus Iran medicine.disease_cause Gastroenterology Renal Dialysis Risk Factors Seroepidemiologic Studies Virology Internal medicine Prevalence medicine Humans Seroprevalence False Positive Reactions education Hepatitis education.field_of_study Hepatology medicine.diagnostic_test business.industry Incidence (epidemiology) Transfusion Reaction Middle Aged medicine.disease Hepatitis C Tissue Donors digestive system diseases Infectious Diseases Immunology Female business Liver function tests |
| Zdroj: | Journal of Viral Hepatitis. 9:390-392 |
| ISSN: | 1365-2893 1352-0504 |
| DOI: | 10.1046/j.1365-2893.2002.00368.x |
| Popis: | Hepatitis C virus (HCV) seroprevalence and risk factors in north Iran were investigated in 105 thalassemia sufferers 93 haemodialysis patients and 5976 blood donors by second generation ELISA. Our study showed that haemodialysis patients and thalassemia sufferers were at higher risk of having HCV infection; the prevalence being 55.9% and 63.8% respectively in comparison to the prevalence of blood donors (0.5%). A confirmatory immunoblotting was employed using HCV-positive cases (54 thalassemia sufferers and 19 blood donors). The result showed that 92.6% of samples of the first group and 10.5% of the latter were positive. Thus it can be suggested that ELISA in low-risk cases may produce considerable false positives. In HCV positive patients with thalassemia the incidence of HCV among different age groups and genders was similar but a strong correlation in respect to the number of blood transfusion (P = 0.008) was observed. In HCV-positive haemodialysis patients it was found that there was no correlation with liver function tests (alanine aminotransferase and aspartate aminotransferase: ALT and AST) but a significant correlation was observed in respect to the duration of dialysis (P = 0.000) and the number of units transfused (P = 0.000). Consequently it still seems blood transfusion is the main factor for increasing the incidence of HCV in thalassemia sufferers and haemodialysis patients. (authors) |
| Databáze: | OpenAIRE |
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